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17.4 Liver Diseases Unique to Pregnancy page 553 17.4.1 ACUTE FATTY LIVER OF PREGNANCY Acute fatty liver of pregnancy is characterized by fatty infiltration of the liver. It may rapidly progress to hepatic failure pms and death. Acute fatty liver may be uncommon (1 in 13,328 deliveries), but is important, having a maternal mortality of 18% and fetal mortality of 23%. The etiology is pms unknown, but the microvesicular fat that accumulates in hepatocytes probably represents disordered intermediary fat metabolism, perhaps related to mitochondrial injury. Acute fatty liver of pregnancy almost invariably presents in the third trimester, with a pms peak frequency around 36-37 weeks gestation. Occasionally, it will become apparent only after delivery. There is an association with nulliparity, twin gestations, male fetus and pre-eclampsia or eclampsia.
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