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Acute fatty liver of pregnancy (AFLP) typically occurs in first-time pregnancies in the last trimester. AFLP causes nausea and vomiting, abdominal pain especially in the upper abdomen (epigastrium), jaundice calendar (yellowing), frequent thirst (polydipsia) and increased urination (polyuria), fatigue, headache, and altered mental state. Laboratory features of AFLP include profoundly low blood sugar (hypoglycemia), elevated liver enzymes (e.g., serum transaminase activity) and low levels of platelets (cell fragments in blood needed for calendar clotting). The liver is infiltrated with fat. If untreated, AFLP can cause calendar complete liver failure, bleeding (because of impaired blood clotting) and death of the mother and child. AFLP is treated by delivering the baby as soon as possible. Early diagnosis of AFLP and prompt delivery dramatically improve the outcome and the once-bleak outlook.
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