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| ohio, péter halász, roland joffé, 3 fatmen, bigclothesforbigpeoplewithbigattitude, alamogordo, merchandising, low fat food, fat men, allan corduner, | O'Rahilly's team saw for themselves how the youngsters gorged: site w the boy would put away 2500 calories at a single meal, and still be up for more.The scientists discovered that the children had a genetic mutation which meant they lacked a protein called leptin. Leptin had been site w discovered a few years earlier by scientists in the US site w working with an insatiable mutant mouse strain called ob. The huge, ever hungry ob mice had also lacked leptin; given it, they rapidly slimmed down. If the obese cousins were given synthetic human leptin, perhaps their desperate desire to eat would fade away, too. It took months to get permission from clinical regulators, but when the children started receiving injections of the substance, the effect was astonishing. |
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| LRB | Vol. 25 No. 15 dated 7 August 2003 | James Meek printable layout tell a friend Trillion Dollar Disease James Meek The Hungry Gene: The Science of Fat and the Future of Thin by Ellen Ruppel allan corduner Shell · Atlantic, 294 pp, £17.99A few years ago, Stephen O'Rahilly, a professor of metabolic medicine at Cambridge and consultant of last resort for allan corduner the dangerously overweight, had two cousins from the Punjab referred to him for treatment. One was an eight-year-old girl who weighed allan corduner almost 190 pounds and was too heavy to walk. The other was a two-year-old boy. He tipped the scales at 65 pounds. The parents described the children's ravenous appetites, which no amount of food could sate, how they foraged in rubbish bins for discarded chips, and stole fish fingers from the freezer to chew without waiting for them to thaw. |
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