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Cholestatis of pregnancy Cholestatis of pregnancy is a condition of unknown cause. It usually arises late in the third trimester of pregnancy. The primary symptom associated with it is extreme itchiness. There may also be mild jaundice (yellowing of queen fat bottomed girls the skin due to excess bilirubin). The laboratory evaluation in such patients reveals a tremendous increase queen fat bottomed girls in alkaline phosphatase to 7-10 times above normal. If the serum bile acids were assayed, it would be found that they are between 10 and 100 times normal. It is this extreme elevation of bile acids queen fat bottomed girls which is felt to cause the generalised pruritis. Liver biopsies which have been performed in such patients show simple biliary status without disruption of the hepatocellular architecture. These changes are completely reversible and return to normal after the pregnancy ends. Cholestatis of pregnancy has no adverse effect on pregnancy and the cure of the problem is the delivery of the foetus Attempts at using ion exchange resins such as cholestyramine to try to lower the serum bile acids have been uniformly unsuccessful due to the tremendous elevation in these bile acids.
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