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Last revised on September 27th, 2000 Glossary AFLP is "acute fatty liver of late pregnancy" a syndrome in which the clinical presentation is malaise, nausea, vomiting, abdominal pain in the 3rd trimester, elevated aminotransferases (AST, ALT), ultrasound findings, and the exclusion of viral or toxic hepatitis or biliary tract disease. It is considered a life-threatening condition, with an 18 percent maternal and a 23 percent fetal mortality rate. conditions Symptoms associated with acute fatty liver of pregnancy include anorexia, nausea, emesis, conditions abdominal pain, jaundice, headache and central nervous system disturbances. conditions Hepatic histopathology reveals pericentral microvesicular fat with minimal inflammation or necrosis. The laboratory abnormalities in acute fatty liver of pregnancy include moderate elevations of transaminase levels (AST and ALT less than 1,000 IU per L), prolongation of prothrombin time and partial thromboplastin time, decreased fibrinogen, renal failure, profound hypoglycemia and bilirubin levels of 1 - 10 mg per dL (17 - 17 µmol per L).
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