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Normal serum values:"indirect" 3-11 µmol/L; "direct" 0-7. The "direct" values rise in obstruction to bile flow; the "indirect" values rise with damage to glycerol and fatty acids the liver cells as in hepatitis anfd also when excessive hemolysis is occurring. Carnitine Palmitoyl Transferase I & II (CPT I & CPT II glycerol and fatty acids ) are important enzymes required in the oxidation glycerol and fatty acids of fatty acids. Their formation depends on the presence of two genes, CPT1 and CPT2 respectively. A recently discovered mutant , "G710E", of the liver isoform of CPT1 has one base is substituted for another in the gene for liver CPT I transferase. This results in the replacement of single amino acid glutamic acid by serine in position 710 of the enzyme, producing an *allele* of CPT1 that has almost no transferase activity.
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