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Pregnancy does not alter the expected values for serum bilirubin, aminotransferases, g-glutamyl transpeptidase or 5'-nucleotidase, or the INR/prothrombin time. Dilution from the expanded plasma volume causes a 10 'minerals (dietary)' g/L fall in serum albumin and in total protein. Alkaline phosphatase, primarily of placental and skeletal origin, increases 1.5 times normal after the fifth week. Alkaline phosphatase may remain elevated for up to six weeks after delivery. There is an increase in serum globulin, total cholesterol and triglyceride. Liver diseases occurring during pregnancy can 'minerals (dietary)' be divided into three categories: (1) acute liver disease 'minerals (dietary)' coincident with pregnancy; (2) pregnancy occurring in a patient with established chronic liver disease; and (3) liver diseases unique to pregnancy. 17.2 Acute Liver Disease Coincident with Pregnancy page 552 Any liver disease that can afflict young women may arise during pregnancy. Of these, viral hepatitis is the most common cause of jaundice in pregnancy.
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