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Presentation can vary from nonspecific symptoms to fulminant hepatic failure. Nausea and vomiting with or without abdominal pain are common. Examination may reveal a tender liver. Pruritus is uncommon and would suggest the possibility of a different liver fatty liver problem such as intrahepatic cholestasis of pregnancy. Progressive hepatic failure then rapidly supervenes, with the development fatty liver of jaundice, generalized bleeding from coagulopathy, hypoglycemia, hepatic encephalopathy and renal failure. Such severe cases have an inexorable downhill course unless the fetus is delivered; even then, deterioration may continue for a fatty liver further 48 to 72 hours. Laboratory features include a moderately elevated aminotransferase, which is usually around 300 IU/L but may range from normal to 1,000 IU/L.
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